There are three steps in manufacturing a screw: heading, thread rolling, and coating. Screws are normally made from wire, which is supplied in large coils, or round bar stock for larger screws. The wire or rod is then cut to the proper length for the type of screw being made; this workpiece is known as a blank. It is then cold headed, which is a cold working process. Heading produces the head of the screw. The shape of the die in the machine dictates what features are pressed into the screw head; for example a flat head screw uses a flat die. For more complicated shapes two heading processes are required to get all of the features into the screw head. This production method is used because heading has a very high production rate, and produces virtually no waste material. Slotted head screws require an extra step to cut the slot in the head; this is done on a slotting machine. These machines are essentially stripped down milling machines designed to process as many blanks as possible.

The blanks are then polished again prior to threading. The threads are usually produced via thread rolling; however, some are cut. The workpiece is then tumble finished with wood and leather media to do final cleaning and polishing. For most screws, a coating, such as electroplating with zinc (galvanizing) or applying black oxide, is applied to prevent corrosion.

Threaded fasteners either have a tapered shank or a non-tapered shank. Fasteners with tapered shanks are designed to either be driven into a substrate directly or into a pilot hole in a substrate, and most are classed as screws. Mating threads are formed in the substrate as these fasteners are driven in. Fasteners with a non-tapered shank are generally designed to mate with a nut or to be driven into a tapped hole, and most would be classed as bolts, although some are thread-forming (eg. taptite) and some authorities would treat some as screws when they are used with a female threaded fastener other than a nut.

Sheet-metal screws do not have the chip-clearing flute of self-tapping screws. However, some wholesale vendors do not distinguish between the two kinds.
A wood screw is a metal screw used to fix wood, with a sharp point and a tapered thread designed to cut its own thread into the wood. Some screws are driven into intact wood; larger screws are usually driven into a hole narrower than the screw thread, and cut the thread in the wood. Early wood screws were made by hand, with a series of files, chisels, and other cutting tools, and these can be spotted easily by noting the irregular spacing and shape of the threads, as well as file marks remaining on the head of the screw and in the area between threads. Many of these screws had a blunt end, completely lacking the sharp tapered point on nearly all modern wood screws. Some wood screws were made with cutting dies as early as the late 1700s (possibly even before 1678 when the book content was first published in parts). Eventually, lathes were used to manufacture wood screws, with the earliest patent being recorded in 1760 in England. During the 1850s, swaging tools were developed to provide a more uniform and consistent thread. Screws made with these tools have rounded valleys with sharp and rough threads.

Once screw turning machines were in common use, most commercially available wood screws were produced with this method. These cut wood screws are almost invariably tapered, and even when the tapered shank is not obvious, they can be discerned because the threads do not extend past the diameter of the shank. Such screws are best installed after drilling a pilot hole with a tapered drill bit. The majority of modern wood screws, except for those made of brass, are formed on thread rolling machines. These screws have a constant diameter and threads with a larger diameter than the shank and are stronger because the rolling process does not cut the grain of the metal.
A self-tapping screw is designed to cut its own thread, usually in a fairly soft metal or plastic, in the same way as a wood screw (wood screws are actually self-tapping, but not referred to as such).

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The hand tool used to drive in most screws is called a screwdriver. A power tool that does the same job is a power screwdriver; power drills may also be used with screw-driving attachments. Where the holding power of the screwed joint is critical, torque-measuring and torque-limiting screwdrivers are used to ensure sufficient but not excessive force is developed by the screw. The hand tool for driving hex head threaded fasteners is a spanner (UK usage) or wrench (US usage), while a nut setter is used with a power screw driver.

Modern screws employ a wide variety of screw drive designs, each requiring a different kind of tool to drive in or extract them. The most common screw drives are the slotted and Phillips in the US; hex, Robertson, and Torx are also common in some applications. Some types of drive are intended for automatic assembly in mass-production of such items as automobiles. More exotic screw drive types may be used in situations where tampering is undesirable, such as in electronic appliances that should not be serviced by the home repair person.